Mirko Zierke

Mirko Zierke

Swiss National Science Foundation (SNSF) Postdoctoral Fellow

 

  • 2013-2014   Postdoctoral Fellow, University of Basel, Switzerland, Supervisor: Prof. Beat Ernst (Institute of Molecular Pharmacy)
  • 2009 – 2013    Ph.D. (Pharmaceutical Sciences), University of Basel, Switzerland, Supervisor: Prof. Beat Ernst (Institute of Molecular Pharmacy)
  • 2012    Visiting Researcher, ETH Zurich, Switzerland, Institute of Molecular Biology and Biophysics
  • 2007 – 2009    M.Sc. (Life Science), University of Konstanz, Germany, Supervisors: Prof. Marcus Groettrup (Chair of Immunology) and Prof. Richard R. Schmidt (Department of Chemistry)
  • 2004 – 2007    B.Sc. (Life Science), University of Konstanz, Germany
  • 1999 – 2002    Industrial training as chemical laboratory assistant, Altana Pharma, Germany

 

Phone: 604-822-8847
Email: zierkem(at)chem.ubc.ca

 

RESEARCH INTERESTS

  • Design and development of antagonists/inhibitors of carbohydrate binding proteins using chemoenzymatic and chemical synthesis strategies
  • Kinetic evaluation of amylase, xylanase and cellulase inhibitors
  • Synthesis of fluorescent-tagged glycosidase inactivators for the development of activity-based proteomic tools to profile, identify and quantify active enzymes within complex mixtures

 

PUBLICATIONS

  • Thomas Aeschbacher,Mirko Zierke, Mayeul Collot, Martin Smieško, Jean-Maurice Mallet, Beat Ernst, Frédéric H.-T. Allain, Mario Schubert; The Solution Conformation of Lewisx is Locked by a C-H···O Hydrogen Bond. Chem. Eur. J.. 2017, accepted, doi:10.1002/chem.201701866
  • Mirko Zierke, Tina S. Rasmussen, Stephen G. Withers; Glycosidase Inhibitors and Use Thereof for Monitoring Enzymatic Processes in Biotechnology. US Provisional patent application; Publication date: 18th of May 2017; Application number: US 62/508,248.
  • Mirko Zierke, Martin Smieško, John M. Peterson, John L. Magnani, Beat Ernst; E-Selectin Antagonists Modified by Macrocycle Formation to the Galactose. US Patent application; Publication date: 23th of July 2015; Application number: PCT/US2015/011523; Publication No. WO2015109049 A1.
  • Mirko Zierke, Martin Smieško, Said Rabbani, Thomas Aeschbacher, Frédéric H.-T. Allain, Mario Schubert, Beat Ernst; The Solution Conformation of Lewisx is Locked by a C-H···O Hydrogen Bond. J. Am. Chem. Soc. 2013, 135(36): 13464-72.