Publications: 1974-1985

Day, A.G. and Withers, S.G. (1985) Biochem. Biophys. Res. Commun. 133, 628-632 “A simple kinetic test to distinguish exo-glucosidase and b -glucosidase activities”. Pubmed

 

Withers, S.G., Madsen, N.B. and Sykes, B.D. (1985) Biophys. J. 48, 1019-1026 ” 31 P-NMR relaxation studies of the activation of the coenzyme phosphate of glycogen phosphorylase. The role of motion of the bound phosphate”. Pubmed

 

Withers, S.G. (1985) J. Biol. Chem. 260, 841-845 “Pyridoxal-(5′)-diphospho-(1)- a -D-glucose; a potent R-state inhibitor of glycogen phosphorylase”. Pubmed

 

Withers, S.G., Madsen, N.B. and Sykes, B.D. (1985) J. Mag. Res. 61, 545-549 “Relaxation of individual transitions in an AX spectrum: Use of interference terms to separate the dipolar and chemical shift anisotropy contributions to the relaxation of 31 P and 19 F nuclei in macromolecules”.

 

Madsen, N.B. and Withers, S.G. (1984) Prog. Clin. Biol. Res. 144a, 117-126 “The catalytic mechanism of phosphorylase; novel role of the coenzyme phosphate”. Pubmed

 

Withers, S.G., Madsen, N.B. and Sykes, B.D. (1982) Biochemistry 21, 6716-6722 “Covalently activated glycogen phosphorylase: A phosphorus-31 nuclear magnetic resonance and ultracentrifugation analysis”. Pubmed

 

Withers, S.G., Shechosky, S. and Madsen, N.B. (1982) Biochem. Biophys. Res. Commun. 108, 322-328 “Pyridoxal phosphate is not the acid catalyst in the glycogen phosphorylase catalytic mechanism”. Pubmed

 

Withers, S.G., Madsen, N.B., Sprang, S.R. and Fletterick, R.J. (1982) Biochemistry 21, 5372-5382 “Catalytic site of glycogen phosphorylase: Structural changes during activation and mechanistic implications”. Pubmed

 

Sprang, S.R., Goldsmith, E.J., Fletterick, R.J., Withers, S.G. and Madsen, N.B. (1982) Biochemistry 21, 5364-5371 “Catalytic site of glycogen phosphorylase: Structure of the T-state and specificity for a -D-glucose”. Pubmed

 

Withers, S.G., Madsen, N.B, Sykes, B.D., Takagi, M., Shimomura, S. and Fukui, T. (1981) J. Biol. Chem. 256, 10759-10762 “Evidence for direct phosphate-phosphate interaction between pyridoxal phosphate and substrate in the glycogen phosphorylase catalytic mechanism”. Pubmed

 

Withers, S.G., Madsen, N.B and Sykes, B.D. (1981) Biochemistry 20, 1748-1756 “Active form of pyridoxal phosphate in glycogen phosphorylase. Phosphorus-31 nuclear magnetic resonance investigation”. Pubmed

 

Withers, S.G. and Madsen, N.B. (1980) Biochem. Biophys Res. Commun. 97, 513-519 “Nucleotide activation of glycogen phosphorylase b occurs only when the nucleotide phosphate is in a dianionic form”. Pubmed

 

Legler, G., Sinnott, M.L. and Withers, S.G. (1980) J. Chem. Soc. Perk. Trans., II, 1376-1383 “Catalysis by b -glucosidase A 3 of Aspergillus wentii”.

 

Withers, S.G., Kasvinsky, P.J., Madsen, N.B. and Sykes, B.D. (1979) Biochemistry 18, 5342-5348 “Identical structural changes induced in glycogen phosphorylase by two non-exclusive allosteric inhibitors”. Pubmed

 

Withers, S.G., Yang, D.S.C., Madsen, N.B. and Fletterick R.J. (1979) Biochem. Biophys Res. Commun. 86, 1044-1050 “A systematic approach to isomorphous replacement using a series of simple charged mercurials”. Pubmed

 

Loeffler, R.S.T., Sinnott, M.L., Sykes, B.D. and Withers, S.G. (1979) Biochem. J. 177, 145-152 “Interaction of the lac z b -galactosidase of Escherichia coli with some b -D-galactopyranoside competitive inhibitors”. Pubmed

 

Withers, S.G., Jullien, M., Sinnott, M.L., Viratelle, O.M. and Yon, J.M. (1978) Eur. J. Biochem. 87, 249-256 “Dependence upon pH of steady state parameters for the b -galactosidase catalysed hydrolysis of b -galactopyranosyl derivatives of different chemical types”. Pubmed

 

Sinnott, M.L., Withers, S.G. and Viratelle, O.M. (1978) Biochem. J. 175, 539-546 “The necessity of Mg ++ for acid assistance of aglycone departure in catalysis by E. Coli (lac z) b -galactosidase”. Pubmed

 

Sinnott, M.L., Viratelle, O.M. and Withers, S.G. (1975) Biochem. Soc. Trans. 3, 1006-1009 “pH and magnesium ion dependence of the hydrolyses of b -D-galactopyranosyl pyridinium salts catalysed by Escherichia Coli b -galactosidase”.

 

Sinnott, M.L. and Withers, S.G. (1974) Biochem. J. 143, 751-762 “The b -galactosidase catalysed hydrolyses of b -D-galactopyranosyl pyridinium salts”. Pubmed