Andreas Geissner

Leopoldina Postdoctoral Fellow

Education

Since 2017: Postdoctoral Fellow at The University of British Columbia
2012-2017: Graduate Studies (Dr. rer. nat); Freie Universität Berlin and Max Planck Institute of Colloids and Inferfaces; Portsdam, Germany
2009-2012: Master of Science in Biochemistry; University of Regensburg; Germany
2006-2009: Bachelor of Science in Biochemistry; University of Regensburg; Germany

Google scholar profile: https://scholar.google.de/citations?user=aEWzVXEAAAAJ

Research Interest:

I am interested in various aspects of glycobiology, especially in the context of glycan-protein interactions, interactions of glycans with immune receptors, and glycans as important structural feature of biotherapeutics. My current research focuses on employing synthetic biology to the development of techniques to improve production and efficiency of biotherapeutic proteins.

Publications:

Original research articles
Hanske, J., Wawrzinek, R., Geissner, A., Wamhoff, E.-C., Sellrie, K., Schmidt, H., Seeberger, P. H., and Rademacher, C. (2017) Calcium-independent activation of an allosteric network in Langerin by heparin oligosaccharides, ChemBioChem. 1183–1187
Weishaupt, M. W., Hahm, H. S., Geissner, A., and Seeberger, P. H. (2017) Automated glycan assembly of branched β-(1,3)-glucans to identify antibody epitopes, Chem. Commun. 53 3591–3594
Parameswarappa, S. G*., Reppe, K*., Geissner, A*., Ménová, P., Govindan, S., Calow, A. D., Wahlbrink, A., Weishaupt, M. W., Monnanda, B. P., Bell, R. L., Pirofski, L.-A., Suttorp, N., Sander, L. E., Witzenrath, M., Pereira, C. L., Anish, C., and Seeberger, P. H. (2016) A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection, Cell. Chem. Biol. 23, 1407–1416.
Reinhardt, A., Wehle, M., Geissner, A., Crouch, E. C., Kang, Y., Yang, Y., Anish, C., Santer, M., and Seeberger, P. H. (2016) Structure binding relationship of human surfactant protein D and various lipopolysaccharide inner core structures, J. Struct. Biol. 195, 387–395.
Wörmann, X., Lesch, M., Welke, R.-W., Okonechnikov, K., Abdurishid, M., Sieben, C., Geissner, A., Brinkmann, V., Kastner, M., Karner, A., Zhu, R., Hinterdorfer, P., Anish, C., Seeberger, P. H., Herrmann, A., Meyer, T. F., and Karlas, A. (2016) Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells, Virology 492, 118–129.
Geissner, A., Pereira, C. L., Leddermann, M., Anish, C., and Seeberger, P. H. (2016) Deciphering Antigenic Determinants of Streptococcus pneumoniae Serotype 4 Capsular Polysaccharide using Synthetic Oligosaccharides, ACS Chem. Biol. 11, 335–344.
Pereira, C. L., Geissner, A., Anish, C., and Seeberger, P. H. (2015) Chemical Synthesis Elucidates the Immunological Importance of a Pyruvate Modification in the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 4, Angew. Chem. Int. Ed. 54, 10016–10019.
Götze, S., Reinhardt, A., Geissner, A., Azzouz, N., Tsai, Y.-H., Kurucz, R., Varón Silva, D., and Seeberger, P. H. (2015) Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a Toxoplasma gondii mouse challenge model, Glycobiology 25, 984–991.
Schmidt, D., Schuhmacher, F., Geissner, A., Seeberger, P. H., and Pfrengle, F. (2015) Automated Synthesis of Arabinoxylan-Oligosaccharides Enables Characterization of Antibodies that Recognize Plant Cell Wall Glycans, Chem. Eur. J. 21, 5709–5713.
Burrage, J., Termanis, A., Geissner, A., Myant, K., Gordon, K., and Stancheva, I. (2013) The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells, J. Cell Sci. 125, 5524–5534.
Böttger, A., Doxey, A. C., Hess, M. W., Pfaller, K., Salvenmoser, W., Deutzmann, R., Geissner, A., Pauly, B., Altstätter, J., Münder, S., Heim, A., Gabius, H.-J., McConkey, B. J., David, C. N., and Powell-Coffman, J. A. (2012) Horizontal Gene Transfer Contributed to the Evolution of Extracellular Surface Structures: The Freshwater Polyp Hydra Is Covered by a Complex Fibrous Cuticle Containing Glycosaminoglycans and Proteins of the PPOD and SWT (Sweet Tooth) Families, PLoS ONE 7, e52278.

Review articles
Geissner, A., and Seeberger, P. H. (2016) Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications, Annu. Rev. Anal. Chem. 9, 223–247
Geissner, A., Anish, C., and Seeberger, P. H. (2014) Glycan arrays as tools for infectious disease research, Curr. Opin. Chem. Biol. 18, 38–45.